Heisenberg was willing to face the consequences of his realization that our science is always an exploration of the world as it is revealed to us, in space and time. Indeed, the uncertainty principle tells us with enormous precision what the limits on that knowledge are in the world of the very small, just as relativity tells us with enormous precision that what we can know here and now about the larger universe around us is fundamentally limited by the speed of light. Those limits are baked into reality, yes, because our knowledge is also baked in. For what does “position” mean, what does
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