When sin achieves a significant victory due to the neglect of mortification, it breaks the soul's bones (Psalms 31:10; 51:8) and makes a person weak, sick, and near death (Psalms 38:3-5) to the point where they can't even look up (Psalms 40:12; Isaiah 33:24). If someone keeps taking hit after hit, wound after wound, defeat after defeat, without putting up a strong resistance, can they expect anything other than to be "hardened by sin's deceitfulness" (Hebrews 3:13) and for their souls to bleed to death (2 John 1:8)?

