Determined: A Science of Life without Free Will

by Robert M. Sapolsky

The acquisition, consolidation, and extinction[*10] of the conditioned fear of something neutral like a tone reflects the organism’s history even more. Extinction will occur faster if, in the seconds before, there are high levels in the amygdala of endocannabinoids (whose receptor also binds THC, the most active component of cannabis)—this makes it easier to stop being afraid of something. The amygdala becomes less likely to store away a conditioned fear response as a stable memory if, in the previous hours, the individual has taken an SSRI antidepressant like Prozac (which makes people ruminate less about negative thoughts). The amygdala will be less active and harder to condition if, in the days before, it was exposed to high circulating levels of oxytocin, which helps explain how oxytocin can promote trust. In contrast, if the organism has been exposed to high levels of stress hormones in the previous month, it becomes easier to generate a conditioned fear response