There’s a whole cascade of molecules involved in the process of an action potential causing vesicles to dump their neurotransmitter into the synapse—ion channels open or close, ion-sensitive enzymes are activated, a matrix of proteins holding a vesicle still in its inactive state has to be cleaved, a molecular machete has to cut through more matrix to allow the vesicle to then move toward the neuron’s membrane, the vesicle has to now dock to a specific release portal in the membrane.
