It is also true that some of these creative and original scientists are not easy to get along with. They can be impatient. They express themselves too directly when they disagree with you, and they lack the good manners that come easily to those for whom fitting in is more important than being right. Having known several such “difficult” people, I suspect they are angry for the same reason that very smart women in science are sometimes angry: They have suffered a lifetime of being made to feel marginal.