If we delve further into theoretical work from the animal kingdom, we find that animals’ immune systems can be conditioned to respond to placebos, in exactly the same way that Pavlov’s dog began to salivate in response to the sound of a bell. Researchers have measured immune system changes in dogs using just flavoured sugar water, once that flavoured water has been associated with immunosuppression, by administering it repeatedly alongside cyclophosphamide, a drug that suppresses the immune system.