We initially determined whether the amount of protein that we eat could change this enzyme activity. After a series of experiments (Chart 3.218), the answer was clear. Enzyme activity could be easily modified simply by changing the level of protein intake.18–21 Decreasing protein intake like that done in the original research in India (20% to 5%) not only greatly decreased enzyme activity but did so very quickly.22 What does this mean? Decreasing enzyme activity via low-protein diets implied that less aflatoxin was being transformed into the dangerous aflatoxin metabolite that had the
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