tldr: Don't take advice on growing plants from somebody with no experience growing plants.
I would guess the author is an academic, not a farmer. (After checking, the author is indeed an academic with no background or experience in farming.) I'm learning to distinguish the two. Despommier is an ivory tower technophile who recommends farmers take the advice of government agencies and academics despite lacking the expertise to give useful advice. I don't know of any long time farmers who share those characteristics, and for a very good reason: more often than not, government agencies and academics give wrong advice, and a good farmer knows the land better. Despommier offers more bad advice. Academics of the 20th century seem easily blinded to the superior education offered by the land.
A decade ago, I would have swooned for the ideas in this book. Now, I think they are inefficient, counterproductive, and possibly destructive. I see that Despommier is suggesting nothing more than the completion of the abandonment of the farm and nature and the total urbanization of human populations.
Instead of taking people out of ecosystems, we should be playing roles in ecosystems. Instead of keeping people away from centralized farming systems, we need everyone involved in food and soil. The author's vision of the future is a dystopia, where corporations control food production in urban areas and few people are even allowed to see the plants.
It's possible vertical urban soil-less farming in high-security, negative-pressure clean rooms by authorized personnel in single-use PPE will happen at some time somewhere. Possibly it already is. This is a truly impoverished and unsustainable relationship with Mother Nature.
Imagine the costs of building structures that rival what Apple (the computer company, not to confuse this with farming) builds. This is a vision of food for the rich, controlled by the rich. It is fundamentally dystopian. The author recognizes the potential for humanitarian tragedy in his concept, but cavalierly brushes away his misgivings with the assumption that the idea is already out in the public and therefore it must be an inevitability. Lots of ideas have been thrown into the public sphere, but fortunately there is no mandate to develop all of them.
In lieu of expertise in farming, the author copies and pastes oversimplified textbook speculations on the "origins" of farming. Instead of insights into ecosystems and what plants want to be healthy, the author liberally sews the pages with the assumption that tech bros could easily feed humanity if only they could finally get rid of farmers, hunters, foragers, and anyone with actual experience with the land.
In this book, you will find no useful information on ecosystem functions, ecology, plant health, companion planting, urban farming, vertical gardening, agroforestry, regenerative agriculture, farming or food policy, how to farm, or anything at all useful. Instead, you'll find assertions like "burning compost for the electrical energy grid is more efficient than composting compost for the soil."
The author seems to believe nature can heal once humans all leave to live in cities. He ignores the healthy role of traditional human societies in their ecosystems. He ignores the question of where all his high-tech building materials will come from. He ignores population dynamics: if a 100% urban population is ever fully fed by a vegetarian diet from high-security sky scrapers of single-crop plants, that population will again expand into the "human-free nature zones".
The only thing the author proposes that is supported by generations of farming practice is that we should value our poo.
I did enjoy the forward to the book by Majora Carter, but the rest of the book was a waste of time.