A well-done ethnographic study of the different cultures in the high-technology industry in Silicon Valley and the Boston region, coupled with a short history of each.
The Route 128 industry actually started first, after WWII, boosted by the power of MIT and its star pupil Vannevar Bush, who went into the federal government and managed to steer 1/3 of all scientific research contracts into MIT's businesses (how convenient). In 1946 MIT professors even created America's first venture capital company in order to fund these start-ups. The military soon became the single largest buyer of semiconductors and circuits from Route 128 and the region boomed. After Vietnam ended the area transfered all its energies into successful "minicomputers."
Silicon Valley was basically created by MIT-refugee Frederick Terman, who moved to Stanford determined to end the West's reputation for being a semi-colonial backwater. He started the Stanford Industrial Park, along with a number of Stanford-based continuing education programs for businesses (e.g. the Stanford Honors Cooperative Program) and he funded Hewlett Packard out of his own pocket. The region got some high-tech military contracts, but its distance from DC kept it undercapitalized.
In the 1970s, however, Silicon Valley's semiconductor industry surged ahead of the then dominant Route 128, and Saxenian shows why. Silicon Valley had an informal culture, one that rewarded constant innovation, mobility, and disrespect for authority. Most of its corporations were headed by 20- and 30-somethings who had already failed at other ventures and yet who managed to create small, nimble companies that operated in large networks of suppliers. Route 128 businesses, on the other hand, tried to mimic General Motors and General Electric, and had older Harvard-educated leaders. They created vertically-integrated behemoths that could not evolve with the times.
East Coast culture and history also exerted a powerful pull against innovation. One simple contrast demonstrates the difference. Hewlett Packard famously created its audio-oscillator in its founders' garage in Silicon Valley, while the now-defunct Digital Equipment Corporation along Route 128 started in the 200 year-old Assabet Mill of the American Woolen Company. As one employee pointed out, in the East everybody knew everyone's family going back decades, and failure was personally devastating. In the West, no one knew where anyone came from and there were no expectations of immediate success.
Often Saxenian belabors this contrast, and she can get fairly repetitive. She also seems to ignore the success of Apple, which operated by closing itself off and yet created innovative proprietary systems.
Still, this is one of the better books on why some industrial regions evolve and thrive and some die out.