An update: I read this book, and wrote the bulk of this review in 2017 shortly after its release. It gave me a lot to think about. I felt strongly that microdosing might be a viable solution for me, as I have been treatment resistant for the 20 years since I've been diagnosed with bipolar disorder, and because I spent more than a decade since a major burnout in 2007, living with constant clinical depression, unalleviated by antidepressants and various therapies.
I've been microdosing psilocybin, now easy to source online in Canada, for a month now (as of the beginning of March 2020) and find myself in a much better place. I don't think I can ascribe this solely to the psilocybin, as I was already feeling much more motivated than what had become my "usual" for a couple of months before that, but I do find myself drifting away from what has been a constant funk and miserable existence. There are other contributing factors for my improved state, such as having disassociated myself from an abusive narcissistic parent in the last couple of years. But I'm finding that my mentality these days is closer to the one I have when I'm slightly "hypomanic", which usually means I'm filled with lots of creative ideas and enjoy living & people, and never have enough hours in a day... and not so interested in sleeping those days away.
This probably closely resembles a base state for many people, but in my case, having had to deal with trauma and genetic predisposition to anxiety and negative thinking, it comes as a blessing. Like dark clouds clearing away and allowing me to see things in full colour again. I haven't told my shrink about this "medication adjustment" yet, because I wanted to see results before mentioning a form of therapy that isn't yet officially accepted medically nor legally, though I did tell my neurologist recently, who seemed unsurprised and had read studies on the subject and said some people had found it helpful in treating cluster headaches, but not migraines, which is what I consult him for.
In any case, I intend on continuing with this experiment, to see whether it continues helping me find a relatively stable state of contentment and productivity over several seasons. I don't recommend this to anyone unless they are well informed and are aware of the legal risks, and would NOT want any minors to take any of what I say as encouragement to experiment with drugs while their brain is still developing. I made that mistake in my teens and I'm certain it hasn't helped my mental wellbeing in the long run, and am truly grateful I never fell on a "bad batch" to turn me into a permanent psychotic mess. Nowadays, when society is divided by polar opposites on so many levels, the gift of relative sanity and stability is probably the biggest and most desirable luxury anyone can give themselves.
***
This book came to my attention a few months before its release, when a caring friend mentioned that it might be of interest to me. This friend, along with most people who know me, was aware that I struggle daily with my mood disorder, and she was right in thinking I'd be curious to learn about a radically different approach to 'self-medication'.
Ayelet Waldman, like me, has taken just about every pharmaceutical drug available on the market, AND suffered all the accompanying side-effects. Treating a mood disorder such as bipolar disorder is complicated business and usually involves a whole drug cocktail to stabilize both the highs and lows. Approaching menopause, Waldman found that she was becoming more and more out of control, and the feeling she was putting her marriage at risk with repeated angry outbursts along with suicidal thoughts prompted her to seek a solution.
Having studied a book on the subject of microdosing which provided helpful guidelines, and not least of all, having procured a small vial of LSD from a mysterious source, she decided to become her own research subject for a month-long trial which involved taking minute amounts of LSD every three days and journaled any changes she was able to perceive over this period. At the kind of doses she was taking (about one-tenth of a standard hallucinogenic dose), the user experiences no hallucinatory effects whatsoever. Instead, she describes the overall effect of the experience as providing a feeling that one is more focused, more in control and with the general impression that one is just having... a really good day.
Waldman makes it very clear that she is by no means a typical drug user and that in fact, with her background as a Federal public defender, she is probably more cautious than most. She did a lot of reading and research on LSD to discover that it is actually a relatively safe drug and that one is unlikely to ever overdose on it. Furthermore, she was very much against the idea of 'tripping out' or getting high in any way. The doses she was taking did not produce psychotropic effects, which leads Waldman to make some very good points on the merits of legalization of drugs, which might be beneficial for treating individual who do not respond to other pharmaceutical drug regimens. She makes good points on why there is a need replace the ineffective and ultimately racist 'war on drugs', and develop a more practical approach to drug use, to, among other things, allow for more clinical trials and ultimately to give adults a right to decide for themselves whether they would like to alter their consciousness with drugs or not.
I would not say this is a 'general interest' book. I had a keen interest in it because it treats on a subject that is very close to me, but I can imagine someone expecting to read about wild LSD experimentation will be sorely disappointed. My high rating reflects the interest level I had in the information this book procured, and it left me thinking I might be a candidate for this kind of treatment.