A User’s Guide to the Brain was written by a psychiatry professor named John Ratey and published in 2001. Found out from reading the acknowledgements that this book was actually ghostwritten - it started out as a 2000 page research overview John Ratey wrote for his students, and then he hired a ghostwriter to turn it into a book for the general public. It’s kind of a slog to read and it’s definitely dated (containing wrong information in parts), although overall I didn’t regret reading it. If you like pop sci books about the brain (like I do) a lot of the content will be familiar — split brain, Phineas Gage, the homunculus, nature vs nurture — but I thought there was enough new content and fresh perspectives to keep things interesting.
I enjoyed the descriptions in the book of some brain structures that I hadn’t previously read about (or at least remembered reading about) in other pop sci brain books, like the basal ganglia, which, together with the cerebellum, controls movement and automatic reactions, and the anterior cingulate gyrus, which, according to Ratey, gives us free will. Supposedly the anterior cingulate gyrus is the center for free will in the brain because some patients with brain lesions on their anterior cingulate gyrus lose the ability to initiate speech or action (although they can still respond when spoken to), and one patient who had recovered from damage in that area, described the experience as having “no will” (319).
There are, of course, other interpretations of these case studies rather than just that the anterior cingulate gyrus bestows us with spooky free will, but Ratey doesn’t mention them. According to Ratey: “We are not prisoners of our genes or our environment. Poverty, alienation, drugs, hormonal imbalances, and depression don’t dictate failure. Wealth, acceptance, vegetables, and exercise don’t guarantee success. Our own free will may be the strongest force directing the development of our brains, and therefore our lives.” (17) Ok then, I’d like to know the mechanism of action for free will, please? Certainly we should hope we operate as if free will does exist in our day to day lives (“Biological determinism, in recent years, has begun to erode our confidence in our knowledge of what is and is not an issue of morality” (8)) but this can definitely be taken too far, and Ratey does. E.g.: “An often overlooked aspect of the treatment of mental disorders is the connection between the mind and the body. The mind, or free will, can impact on the physical manifestation of illness. The famous case of Broadway actor Yul Brynner, who long starred in The King and I and who seemed to put his cancer into remission for a decade using only his will to counteract it, made many people aware of the strong powers the mind can have over the body.” (374) So I actually am a fan of holistic treatments (which, when they do succeed, ultimately succeed for physical reasons), but there aren’t any RCT studies which show free will can cure cancer yet so that anecdote reads more as offensive and dangerous.
Another main theme Ratey introduces is the idea that what we think of as mental illnesses or personality disorders may be caused by perception deficits or sensory sensitivities. For instance, he tells the story of Delores, who had amassed a long list of mental illness diagnoses, including schizophrenia and antisocial personality disorder. As John Ratey works with Delores as her psychiatrist, he discovers she has strong touch sensitivity, which he then concludes may have been the cause of all of her problems from the very beginning. While this may be true for Delores (or may not - I’m honestly skeptical a touch sensitivity caused schizophrenia-like symptoms), John proceeds to conjecture that perhaps most people who we look at as being “crazy” have all this time merely been suffering from differences in sensory perception. This seems unrealistically optimistic to me - like those books you read in elementary school where the bully was just “misunderstood.” The weirder part are passages where Ratey more or less says (paraphrasing here), what a relief it was to Delores and others like her to find out they weren’t actually ~~~crazy~~~, they just had perceptual disturbances. Weird vibes here, like, if your mental illness is caused by a perceptual disturbance, then you’re somehow in a better league than people who’s mental illnesses are caused by genes/environment. Mental illness, like perceptual disturbance, also is beyond the control of the individual suffering from it: neither need to be stigmatized? (Or if there is some critical social function to stigmatizing mental illness, then both should be stigmatized?)
Because this book was written in the early 2000s and because sometimes people do bad science, there are unfortunately a lot of studies Ratey talks about that have now been proven to be false or not replicable. A few examples: playing classical music to babies makes them smarter, the menstrual cycles of groups of women who live together tend to sync up because pheromones, babies who are taught to sign at a young age will have higher IQs by the age of 4. This is a huge ding for this book because it’s now basically a source of misinformation. Ratey, like most pop sci authors, is also sloppy when mentioning correlational studies, without always mentioning that correlation does not necessarily equate to causation. For instance, he states: “…Moh’s 1993 study of people ages seventy to seventy-nine found that those with more education had more efficient memories and experienced less memory change with the passage of time… Moh suggests that such mental exercising keeps memory strong by reinforcing synaptic connections in the brain.” (220) OR maybe people with brains that are less prone to aging are also more likely to get more years of education?
Another piece of out-of-date information: There is a section suggesting that the purpose of REM sleep is for consolidating memories. I’ve heard this hypothesis before, and there is some evidence suggestive for this, for instance, as Ratey mentions, spiny echidnas are the only mammal that do not have a REM stage during sleep, and they also have disproportionately large frontal lobes (so perhaps they are able to do memory consolidation during the day with all of their extra brain matter, instead of waiting to do it during sleep). However, I’m pretty sure David Linden disproves this in his pop sci brain book. (Unfortunately I don’t have the book easily accessible so I can’t check).
Also, to file under “misguided optimism that leads people to say things that are wrong”: Ratey says that Thomas Edison and Albert Einstein had dyslexia (105), and that for that reason, having dyslexia doesn’t mean you’re dumb. I agree that having dyslexia doesn’t mean you’re dumb, but there’s no actual evidence that either Thomas Edison or Albert Einstein had dyslexia.
Due to the high percentage of this book consisting of false statements, I almost rated it 1 star, but what redeemed it slightly for me was Ratey’s refreshing take on psychiatric drugs. For a psychiatrist, Ratey is unusually cautious about blindly supplying psych drugs to every patient and unusually forthcoming about their side effects. There’s an excellent, though lengthy passage which describes the ways in which psych drugs can impair patients: “In an era when Prozac is taken nearly as often as aspirin, clinicians find it tempting to attack any emotional or behavioral problem with a prescription. Too often symptoms are relieved but not cured, and the relief comes at the expense of other dimensions of the patients’ life. Sedating the overactive brain with medication may calm a patients fears and worries, but it often impairs cognitive ability. Stimulants may lengthen a person’s attention span but compromise creativity. Lithium can stabilize mood swings, but it cripples short-term memory. Neuroleptics can dampen the vivid and terrifying hallucinations of schizophrenic psychoses, yet they often erode motivation and narrow cognitive capacities. Although psychiatry has finally achieved recognition as a medical science, drug therapy is still a crude and primitive tool for treating an organ we are only beginning to understand. Which faculties and sources of satisfaction should a psychiatric patient expect to surrender for the sake of therapeutic convenience? … An individual can exhibit any combination of mild ADHD, OCD, mania, paranoia, depression, autism, or other ‘pathological’ traits to some degree, yet still lead a normal, productive life. Each trait may actually be an adaptive behavioral mechanism to compensate for a neurological deficit.” (338-339)
Ratey is right here. Mood is an additional sense, but for the social world, as opposed to the five senses which probe the physical world. Serotonin and the serotonergic pathways in the brain form the physical basis for mood. If you pour sulfuric acid in one of your ears, your ability to hear might change. If you do the pharmaceutical equivalent with your serotonergic system, your ability to navigate the social world might be compromised.
Misc parts:
“A previous study of Prozac found no effects on IQ, language, or behavior among babies exposed to the drug as fetuses. However, other research indicates an increased rate of ‘minor anomalies’ at birth, such as abnormal creases in the palm of the hand. Until more research is done, women who are taking antidepressants or any medication and are considering pregnancy should consult with their doctors about the risks of continuing or stopping medications on the health of mother and fetus.” (30)
“For their part, would-be fathers would also be wise to avoid exposure to smoking, alcohol, drugs, and toxins for at least three months prior to conception — the life span of sperm.” (30)
“…the ‘neural networks’ that were thought might grow so sophisticated one day that supercomputers could mimic and exceed the capacities of the human brain. These computers have proved terribly inadequate at achieving even the simplest cognitive tasks of the youngest child, such as understanding the meaning of everyday speech. These models fail because they assume that cognition is the result of a series of preset, preprogrammed rules devoid of both meaning and context. If consciousness is a set of programs, then how can you explain an organisms capacities for learning that involve adaptations and development? You can’t. It might be clearer, as suggested by Steve Massaquoi at MIT, for the artificial intelligence field to use the term ‘neuroid network’ to describe its instruments, because ‘neural network’ describes what is going on in the brain, which is simply a different game.” (140-141) Oops, another example of this book aging so, so poorly.
Edelman “neural Darwinism” theory, that neurons compete for connections and resources, and the ones that serve their organism best survive. Edelman also came up with the concept of “reentrant signaling” which as Ratey explains, seems to be the idea that there isn’t a one-to-one mapping of one brain cell corresponding to a person’s knowledge of, say, their grandmother; but rather there is a supermap with then internal mapping spread out over many brain cells and many areas of the brain, where these different maps in different parts of the brain contain different pieces of your grandmother, like a rocking chair, her voice, the concept of an elderly person. This shouldn’t be a terribly surprising to anyone who’s looked at the output of the activation functions for the hidden layers of trained neural networks.
“Damage to the ventromedial cortex is what caused the social problems for Phineas Gage and Elliot. Other historical cases also show the link between such damage and the loss of social skills. The neurotransmitter serotonin may be implicated in the results of damage to the ventromedial cortex. Serotonin has been shown to inhibit aggression in primates and encourage social behavior. Monkeys with good social behavior have more serotonin receptors in their ventromedial cortex than monkeys with poor social behavior.” (311)
Not only does thalidomide cause deformed limbs in fetuses, it also raises their risk of autism by a ton: “… in 33 percent of mothers who, before its use was banned in pregnant women, had ingested thalidomide between days 24 and 27 of pregnancy, their children developed autism, and that fetuses exposed at other times did not… The period between days 24 and 27 of pregnancy is exactly the time that brain neurons are just starting to form.” (327)