As a Trek fan I've been reading IDW's books off and on the past couple of years. What drew me to this crossover was that IDW said this would be their way of wrapping up their various series before moving onto to new series/reboots (I guess we'll see what direction they take).
The basic premise is that Lore, Data's brother, has found a way to alter reality to make him not only supreme being, but as Lore's way to get revenge on those he feels wronged him. And. if Lore doesn't like how things are going? Wipe board time. Wipe it all away and start over again.
But, this is Trek so of course a supreme being makes a mistake/leaves a loophole. Benjamin Sisko, the Prophets emissary starts recalling how things were supposed to be. From there Sisko goes out recruiting past, and in IDW series timeline, current friends and crew to find a way to restore the sacred timeline (couldn't resist that as I finished watching Loki season two yesterday).
For me, reading this as floppies, the most enjoyable piece was seeing where people ended up after reality was restored. Especially, Sisko, Spock and Scott.