Tom Wainwright

“Look at the evolution of the price of a kilogram of the drug, as it makes its way from the Andes to Los Angeles. To make that much cocaine, one needs somewhere in the neighborhood of 350 kilograms of dried coca leaves. Based on price data from Colombia obtained by Gallego and Rico, that would cost about $385. Once this is converted into a kilo of cocaine, it can sell in Colombia for $800. According to figures pulled together by Beau Kilmer and Peter Reuter at the RAND Corporation, an American think tank, that same kilo is worth $2,200 by the time it is exported from Colombia, and it has climbed to $14,500 by the time it is imported to the United States. After being transferred to a midlevel dealer, its price climbs to $19,500. Finally, it is sold by street-level dealers for $78,000.10 Even these soaring figures do not quite get across the scale of the markups involved in the cocaine business. At each of these stages, the drug is diluted, as traffickers and dealers “cut” the drug with other substances, to make it go further. Take this into account, and the price of a pure kilogram of cocaine at the retail end is in fact about $122,000.”
― Tom Wainwright, Narconomics: How to Run a Drug Cartel

“Heroin has a frightening reputation, and rightly so: the margin between an effective dose and an overdose is narrower than that of any other mainstream narcotic. A paper in Addiction, an academic journal, estimated the quantity of various drugs needed to get an average person high versus the amount required to kill them.5 In the case of alcohol, it found that the ratio was about ten to one—in other words, if a couple of shots of vodka are enough to make you tipsy, twenty shots might kill you, if you can keep them down. Cocaine, it found, was slightly safer, with a ratio of fifteen to one. LSD has a ratio of 1,000 to one, whereas marijuana is safest of all: it is impossible to die of overdose, as far as anyone can tell. Even with the edibles, there is no evidence that one can die of overdose—you simply have a stronger and longer-lasting effect than you may have wanted. For heroin, the ratio between an effective dose and a deadly one is just six to one. Given that batches vary dramatically in their purity, each shot is a game of Russian roulette. Dealers”
― Tom Wainwright, Narconomics: How to Run a Drug Cartel