I might have given this a 4-star rating, by I think my expectations were a little too high.
I really enjoyed all of Marvel's Annihilation books, and was expecting this to be something similar... It didn't quite measure up, in my opinion. Bedard writes some good dialogue, and I really like the Vril Dox character. Also, Starro makes a great villain. Part of the problem I have with this is that it seems to crib a lot of plot points from Annihilation, and even a watered-down version of the Gamora character appears, and makes a speech VERY similar to Gamora's. I may be wrong, but I think Annihilation came first.
On the art side, I really loved Andy Clarke's work, and would like to seek out more. Unfortunately, he only drew the first half of this arc. The art in the second half was just passable.
So, I like the characters and plot overall, and I'm somewhat curious to see what happens following the cliff-hanger ending, but overall, it didn't quite deliver to my expectations. Good, but certainly not great.