The first edition of Jim Watson's classic textbook Molecular Biology of the Gene appeared in 1965. This new edition, written with five new authors, has been brought fully up to date, and incorporates insights very recently derived from genome sequencing in a variety of organisms. The book is an authoritative and comprehensive survey of the fundamentals of molecular biology, from basic mechanisms to the elaborate role of gene regulation in embryonic development and evolution. Although updated, the twentyDSone chapters of the new edition retain the distinctive and celebrated features of the original work, including introductory chapters on the history of genetics and molecular biology and an emphasis throughout on the chemical underpinnings of molecular biology. The new team of authors brings to this edition awardDSwinning teaching experience and outstanding research achievements. By revealing the intellectual framework and experimental approaches that made new discoveries in the field possible, the new edition highlights the significance of the molecular approach for all of biology.
In 1928, James D. Watson was born in Chicago. Watson, who co-discovered the double helix structure of DNA (deoxyribonucleic acid) at age 25, was awarded the Nobel Prize in Physiology or Medicine in 1962, along with Francis Crick and Maurice Wilkins. His bird-watching hobby prompted his interest in genetics. He earned his B.Sc. degree in zoology from the University of Chicago in 1947, and his Ph.D. from Indiana University in Bloomington in 1950. He worked with Wilkins and Francis Crick at Cavendish Laboratory in England in 1951-1953, when they discovered the structure of DNA. Watson became a member of the Harvard Biology Department in 1956, then a full professor in 1961. His book The Double Helix, which was published in 1968, became a bestseller. Watson was appointed director of Cold Spring Harbor Laboratory on Long Island in 1968, and became its president in 1994. As director of the National Center for Human Genome Research at the NIH in 1989, Watson launched the worldwide campaign to map and sequence the human genome. Watson was an outspoken unbeliever who considered that human progress had been shackled by the idea of divine fate, and that human beings should do their utmost to improve the future. In a Youngstown State University speech, Watson said, "The biggest advantage to believing in God is you don't have to understand anything, no physics, no biology. I wanted to understand" (The Vindicator, Dec. 2, 2003).
[Yes, Watson's a wacky jerk but] this is hands-down, the best, most in-depth, theoretically useful MolGen textbook out there. Of all the Molecular Biology references I have read, this one has a fresh, brilliant outlook when it comes to the structure-function relationship in both DNA and RNA, and the book is truly worth it even if just for that.
This is the best textbook that I've read. Watson presents the information in a simple to understand way. The information is explained in good detail, and sources are given for the astute student to delve into more depth. This is hands down the best text book of my college days.
This is the best textbook I have ever read. I actually WANT to read it cover to cover. Its easy to read, the explanations are concise and easily understandable. Its really an enjoyable read if you're interested in molecular bio.
Solid foundational textbook on genetics. The writing style is very much focused on discussing experiments and how they proved/demonstrating different facts which added up to a groundbreaking conclusion. It was often very difficult to see the big picture, so it was not the best book to get an understanding of what we know, rather a better book for practicing analyzing observations across experiments.
Fundamental, rich and elaborate starting point to increase one’s knowledge in the ocean of molecular biology. Definitive textbook for CSIR aspirants w.r.t. the subject.
My favourite molecular biology textbook. More dedicated than most, thorough and reasonably up to date. Although I suspect that a new edition should be available soon.
Interesting, but difficult to read as an undergrad - the topics both within a single chapter and among several chapters jumped around, making it hard to study. You have to really sit down and be prepared to read for a long while in order to thoroughly understand main ideas; I prefer to be able to read smaller chunks at a time and still understand both details & the big picture.
Geet: Erik will bring this in for you. It's like Molecular Biology of the Cell (MBotC), but focused on genes. Pro: This book is more concise, and therefore easier to read than MBotC (which tends to ramble). But, it has a narrower topic.
This one is explaining the maintenance of DNA, gene regulation and expression,which leaves you feeling tiny! and amazed by all of this. i loved the flow of topics, and how everything is so complicated yet so organized.
Very comprehensive book. More emphasis is on structures. Enough in-depth knowledge for the students/researchers who are at early stages of their research. I would say read this book after reading basic concepts from some other book. Pictures, Diagrams and figures are the plus point of this book.
Another cover to cover reading as part of my GRE biochemistry preparation. This one is not as fun as Lehninger's Biochemistry but is arguably more accessible.