In the book, author posed some questions to challenge random mutation theory:
- Some forms must require at least two damaging non-beneficial gene mutation to constitute. In statistics term, it is improbable.
- Mutations led to resistance to artificial attack (biology, genetic, etc.) happens much more quickly than mutation led to resistance to natural obstacle (CCC hemoglobin), or even has not happened.
I was not satisfy with the quality of the book. Facts are not diverse, mainly focused in malaria disease, and frankly poorly presented, argument is repetitive and not adapted to each fact, as if author unconsciously shoved the intelligent design theory to each paragraph. Moreover, writing style is exuberantly excessive with uncanny descriptiveness. Hated to read on.
After reading the book, I have updated with other arguments to refute random mutation, or evolution in general, such as Cambrian Period biological boom. These arguments are, in nature, very interesting and trigger much contemplation on the scope and applicability of evolution framework component: selection, random mutation, common ancestry.
IMHO, applicability is far more important and forward-thinking than right or wrong. Mutation is indeed very objective, but when projecting with human endeavor and organization changes, which are sometime very subjective, can be intelligent designed at some micro-or-macro scope. What kind of intelligent, or what scope it must fall, is to be explored.