I finished the book over a month ago and jotted down some very brief notes, but only now have got time to expand on them and type up.
This is an awesome book, not without a few limitations (which are really just my personal interests) but very broad in scope, wide-ranging and multidisciplinary - with aspects ranging from the philosophical, definitional, psychological, and practical implications of pseudoscience.
I was most interested in the philosophical and historical chapters, focussing on what pseudoscience is and how pseudoscience can be distinguished from "real science". What I learnt there is there is no "bright line" between pseudoscience and science - rather, defining the border between these two activities requires the continual process of "boundary work", ie the activities of scientists, bloggers, critical thinkers etc, in patrolling the borders and working to scrutinise what is there, and to define elements as either on one side or the other - science versus pseudo.
I felt the earlier chapters were strongest, in laying out these fundamentals and discussing how pseudoscience works - what are the innate failings of the human brain which allow merchants of false science to succeed in evangelising their message.
Kevin Folta's chapter absolutely stands out for its humour and clarity, particularly in the section about his interactions with a Dr Huber, regarding the purported identification of a new plant pathogen, in crops treated with the herbicide Roundup. This illustrates the importance of narrative and charisma in defeating pseuodoscience: as Trish Greenhalgh has said in a talk about "Evidence in a post-truth world", the science doesn't speak for itself - it needs to be spoken for.
Britt Hermes' chapter is phenomenal because again she brings the issues very vividly to life with her own personal story. In particular, she describes the moment when she realises that she has been working in a naturopathic clinic to treat patients with a drug that was being illegally imported, and which the FDA had impounded. Days later, she had seen a lawyer, quit naturopathy, and started her switch over to working to defend the boundary between science and pseudoscience. She quotes a naturopathy colleague as saying: "all naturopaths walk the line between legal and illegal practices".
I did feel there were some limitations in the book. In Jeff Beall's chapter, he suggests that open access journals facilitate the dissemination of pseudoscience. I am biased in my comment on this (having spent some years working on open access journals), but I do not feel that this is a legitimate criticism, because the problems with peer review are not connected with the type of publication model, and many poor-quality closed access journals exist (and indeed existed well before open access took off).
Seth Kalichman's chapter is also excellent because arguably the area of pseudoscience he discusses (AIDS denialism) has killed more, through an organised form of dissemination of misinformation, than any other. (I really don't have stats on this, it's just my impression). He has written more extensively on this in his book, Denying AIDS (which I strongly recommend). Kalichman writes about how he actually met denialists in person, and interacted with them on social media groups (then discussion boards etc) to research the social networks and processes by which denial was spread. As a result, Kalichman (along with Folta, Hermes and others) give a special level of insight into how pseudoscience comes about - who are the individuals who form the "root nodes", or are the influencers and disseminators? Why do they do what they do?
There were some areas which I felt were somewhat lacking in this book, although it covers a huge range of ground. Beall talks about how particular publication models may help facilitate pseudoscience, but I don't recall much of the book focussing on how "false science" now spreads like wildfire over social media - Twitter and Facebook for example. How should those who do boundary work, use these and other tools to combat pseudoscience? Should scientists actively engage with the purveyors of bullshit over social media? Is it a waste of time? Will it tarnish their reputation? If not them, who should do the pseudohunting? Are these appropriate methods? Is long-form blogging (eg, the efforts of Science-Based Medicine and many other blogs and blog networks) the way forward?
The area of greatest personal concern to me - pseudoscience as it relates to parenting issues - was barely discussed, bar a few small mentions here and there. Kalichman talks a bit about the story of Christine Maggiore, an HIV-positive mother who refused ARVs because of her HIV denialist views, and breastfed her baby; who then became infected (it's impossible to know when or how - it could have been during pregnancy, birth or breastfeeding) and then died as a toddler. Kalichman has previously explained how the girl could have been saved, if the serious illness (an AIDS-defining one) she had just before her death could have been linked to HIV. But for various reasons the girl was never tested for HIV and the reason for her illness was not determined until after her death, when it was far too late.
We live in a time when mothers-to-be are told that having a C-section may disturb their baby's microbiome, and go on to cause chronic ill-health in the child, or maybe this (and other birth "interventions") could cause "epigenetic harm" through "the wrong kind of stress" on the baby. I have seen such suggestions disseminated widely on social media by people who are trying to advocate for mothers' rights in birth and parenting; even those who have professional and ethical responsibilities towards women whose health they are aiming to protect. Are these suggestions science, or pseudoscience? I don't know, but I would love to see a greater array of voices join the groups of critical thinkers who are willing to dispassionately and respectfully break down those claims, scrutinise and discuss them in order to better define the boundaries of science - and thereby place science in its rightful place, as an enterprise dedicated to the benefit of people and society.