Fersht’s Structure and Mechanism in Protein Science is a defining exploration of this new era, an expert depiction of the core principles of protein structure, activity, and mechanism as understood and applied today. A thorough recasting of Fersht’s previous text, the book takes a more general look at mechanisms in protein science, emphasizing the unity of concepts in folding and catalysis and the importance of the relationships between basic chemistry, kinetics, thermodynamics, and structure.
My background is genetics, not biochemistry, so I picked up this book to learn more about proteins. Sometimes chapters cover so much material, that the writing is necessarily dense. Sometimes the writing is just bad. Still, it's a great reference, and I learned a lot, even if some of it passed over my head.