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癌症·免疫与治愈

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如今,癌症与每个人近在咫尺。全世界罹患癌症的人数迅速增长,据世界卫生组织国际癌症研究机构(IARC)估计,仅2018年新增1810万癌症病例——其中有48%在亚洲,死亡人数高达960万。这样下去,到本世纪末癌症将成为全球头号“杀手”,因此有人将肿瘤视为“众病之王”。

一直以来,在癌症和人类之间,有一场艰难的、代价惨重的战争。传统癌症治疗方法主要有三种:手术、放疗和化疗。这些“切割、燃烧和毒杀”癌细胞的技术,不但有强烈的副作用,而且只能够治愈一部分癌症患者,而剩下的另一半癌症患者急需更好的治疗方法。

与化疗等损伤性旧疗法不同,主动免疫的应用和被动免疫(预示了一种新的、经过改进的武器的诞生,它将在抗击癌症的战争中充分释放巨大的潜能。这种前景光明的新疗法就是2018年斩获诺贝尔生理学或医学奖的免疫疗法。它是一种全新的治疗思路,借助免疫系统的力量来对抗癌细胞。

这本书是一部免疫肿瘤学的演化史,主要讲述了免疫疗法在治疗癌症方面取得的非凡成功——尤其是在过去的四分之一个世纪里,包括人类对癌症的理解如何演变,以及肿瘤与免疫系统的动态相互作用如何得到越来越深刻的认识。在这段鼓舞人心的历程中,我们将会见到各种用来瞄准难以捉摸的肿瘤细胞的药物和治疗方法,看到突破性科学进展的积累如何迅速转化为拯救生命的技术应用,这些技术已开始极大地提升癌症患者的生命质量和数量。我们也会看到无数科学家、药物研发人员和癌症患者及其家属做出了怎样可歌可泣的贡献和牺牲,有着多么动人心弦的故事。作者还在书中穿插了自己的科研和人生故事,作为这段癌症免疫疗法发展史的有力佐证。

免疫疗法改变了患有转移性黑色素瘤等疾病的患者的预后,在过去的十年里,这种疾病的治疗方法发生了根本性变化,一部分患者已经被治愈,更多的人会很高兴地同意这种预后方案。这种光明的前景属于IO(Immuno-Oncology,免疫肿瘤学)。展望未来,正如1942年11月10日丘吉尔发表的题为"The End of the Beginning"的演讲中所说那样:“这不是结束,甚至这也并非结束的序幕已然到来,但或许,这是序幕已经结束!”也就是说,免疫疗法有望成为癌症的终结者,结束艰难对抗癌症的时代。

360 pages, Paperback

Published September 1, 2021

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Michael Kinch

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Displaying 1 - 6 of 6 reviews
15 reviews
August 9, 2019
A good primer on the development of immuno-oncology, but muddied by numerous long-winded historical asides and lack of thematic progression between chapters. A glossary and immunology schematics would have been helpful; also some editorial presence to eliminate typos and run-on sentences.
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27 reviews6 followers
November 18, 2021
Very interesting review of the most recent studies in cancer cure and well researched compiled history of the disease. Some parts could be tightened up but it's probably aimed at those who are not well-versed in the subject.
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1 review
December 10, 2021
Lots of good info and very interesting but the large number of things that should have been noticed during editing tended to disrupt the flow.
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2,872 reviews
June 11, 2019
Cancer is a frightening word. Even with all the advancements in early diagnosis, screenings tests, and chemotherapy, it's still a word that no one wants to hear. My dad died of advanced cancer 9 years ago. They couldn't even tell where it has started and it was too late to matter. He died a week later.

So if you hand me a book about what's next in the treatment of the disease, I will definitely read it. This book, however, really exceeded my expectations. There's so much in here, from what cancer is exactly and how humans came to understand the disease to how we began to fight it.

It's incredibly rich and detailed. I wouldn't call it an easy read. It's full of names and scientific concepts you will never have heard of. But it was fascinating stuff. And for all the assumptions that people have about the disease, I came away from the book feeling quite positive about the future. So many brilliant researchers are working on so many different treatments. One way or another, humans are going to beat this disease.
Displaying 1 - 6 of 6 reviews