Flesh Made New: The Unnatural History and Broken Promise of Stem Cells

by John Rasko, Carl Power

The dazzling promise of stem cell does it work and will it save us? Two experts look at the hypeFor decades, we've been anticipating the dawn of regenerative medicine. Again and again, we've been promised that stem cells will soon cure just about every ill imaginable. If not tomorrow, then the next day, or the day after that, and so on. We're still waiting.This book is an antidote to hype and a salve to soothe the itch for stem-cell salvation. In it, Professor John Rasko, a leading physician-scientist, and writer-historian Carl Power take us on a wild historical tour of this scandal-prone field. They expose all the dirty little secrets that the hype merchants prefer to ignore - the blunders and setbacks, confusions and delusions, tricks and lies. You'll meet Alexis Carrel, who discovered how to cultivate cells in a test celebrity surgeon, scientific genius and suspected Nazi sympathiser, he opened the field of modern cell science with an experiment so bogus it blocked the way forward for the next 50 years. You'll meet Don Thomas, who developed bone marrow transplantation - the first successful stem-cell therapy - but only after a miserable decade in which most of his patients died. Alongside true stem-cell pioneers, you'll meet charlatans who cooked their data and claimed fake cures - sometimes with fatal consequences.Is there any good news? Which of the many promises of stem-cell research have been kept? And what of the future? Rasko and Power insist that we can only know where we're going if we have a sense of where we've been. Their study tears down the hype surrounding stem cells in order to reveal what's still worth hoping for.PRAISE'If you love some scandal with your science - or some science with your scandal - this is THE book for you. Brilliant stuff' Adam Spencer, University of Sydney'Science, skulduggery and snake oil salesmen ... it is a revolution in medicine but who knew the story of stem cell science was such a ripping yarn!' Fran Kelly, ABC Radio National Breakfast'Science isn't it's a human enterprise. This enthralling book tells of high achievement and astonishing blunders in a vital field of research' Robyn Williams, science journalist and broadcaster'A masterpiece in myth-busting which helps separate fact from fiction in the world of regenerative medicine. It shines a light on some episodes in medical history many would rather forget but also shows a way forward for stem cell research breakthroughs grounded in solid science' Sophie Scott, national medical reporter, ABC'The stem cell myths, mistakes but mighty medical masterpiece' Sir Gustav Nossal, AC CBE FRS FAA, Australian of the Year 2000'A compelling (and compulsory) read for anyone entranced by the latest media-promoted breakthroughs in medical research, or planning translation of new biomedical research into clinical practice' Ian Frazer, AC, FRCPE, FRCPA, FAA, FTSE Australian of the Year 2006, Australian Living Treasure 2012'Is it really stem cells' turn to revolutionise health care? When you come across a train wreck, keep reading! You'll discover that stem cells reveal medicine in its most provocative and challenging light' Antony Basten AO FAA FTSE' Flesh Made New is a revelation for the general reader about what lies beneath the surface of exciting scientific advances ... The book shows the value of patience and trust in robust evidence-based scientific research, and where things go off the rail, for whistleblowers and experts like the authors of this book' Lucy Turnbull AO, businesswoman, urbanist and philanthropist

Genres: Science, Nonfiction, Medical

400 pages, Kindle Edition

Published February 1, 2021

Reviews

[Matty · Rating 5 out of 5]

This was a surprisingly fun read! Such an interesting topic, the history of stem cell research, and made all the more by focusing on the medical mishaps and scandals along the way. Did I understand every little thing I read? No! Because I’m not a scientist- but the authors are great at explaining things in a clear and well-written way, taking the time to summarise what’s been said and the larger point being made. An eye-opening look at the competitive element of cutting-edge science and how a lot of the time, the promise of an amazing cure isn’t what it’s cracked up to be. You’ll like if you’ve also read Bad Blood!

[David W. W. · Rating 5 out of 5]

Better foresight comes from better hindsight. So, anyone interested in the likely future scenarios for regenerative medicine will find much to ponder in "Flesh Made New: The Unnatural History and Broken Promise of Stem Cells" by John Rasko and Carl Power.

The authors weave together a riveting narrative of the history and prehistory of stem cell therapies, including lots of heroics, many failures and misunderstandings, and, yes, some marvellous successes too. It's frequently shocking. And it has many warnings about future missteps.

There are painful lessons about the dangers of hype, over-excitement, "fake it until you make it", over-respect for apparent authorities, disregard for replicability, races to publish, etc. The flaws of the villains are writ large, but with some sympathy provided when appropriate.

However, alongside the instances of bad science, the writers emphasize that stem cell treatments still have a great deal of promise - from bone marrow transplants forward. It's an encouraging vision for the future. Thoroughly recommended!