The Organic Chemistry of Drug Design and Drug Action

by Richard B. Silverman

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors drugs not yet developed are thus covered!


* Emphasizes the use of the principles of physical organic chemistry as a basis for drug design
* Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes
* Uses figures and literature references extensively throughout
* This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

Genres: Chemistry, Science, Nonfiction

422 pages, Hardcover

First published January 1, 1992

Reviews

[Laura]

The movie was definitely better.

[Rebecca]

Fantastic

[Ranjan Acharyya]

ood

[Abigail Gibbons]

interesting

ch 8 was kinda wordy

[Jeffrey Romine]

I very much liked the presentation of SAR in terms of mapping out the pharmacophore. I also thought the chapters at the end on metabolism and prodrugs were about the best I've seen.

[Elizabeth]

I heard Richard B. Silverman at a seminar he gave for the Pharmacology Department, "Selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative inhibitors" (thought I probably would have just left the title at "Selective neuronal nitric oxide synthase inhibitors", or, better yet, "Inhibitors that are selective for nNOS over eNOS or iNOS").