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224 pages, Paperback
First published July 1, 2000
"An experiment on an animal gives no certain indication of the result of the same experiment on a human being."
- Robert Koch, microbiologist and Nobel Prize winner (Medicine)
Fleming might have thrown his penicillin away entirely if he had tried it first on guinea pigs or Syrian hamsters instead of rabbits. It kills them. In addition, penicillin is teratogenic in rats, causing limb malformations in offspring. Fleming stated, "How fortunate we didn't have these animal tests in the 1940s, for penicillin would probably never been granted license, and possibly the whole field of antibiotics might never have been realized."
Rat colon tumors kill by obstructing the colon. Human colon cancer kills by metastasizing to other places in the body. The tumors of the rat bowel do not usually spread. In rats, it is most often the small bowel that is affected; in humans it is the large bowel or colon.
No matter how exhaustive the animal testing, problems can still develop. Fanclozic acid, a potential new anti-inflammatory drug, showed no side effect in mice, rats, dog, rhesus monkeys, patas monkeys, rabbits, guinea pigs, ferrets, cats, pigs, cows, or horses. But the drug caused acute cholestatic jaundice, a type of liver failure, in humans.