On the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest. The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however. A single 100-year-old tree provides only about one dose of the drug (roughly 300 mg). For this reason, as well as the spectacular molecular architecture of Taxol, synthetic organic chemists fiercely undertook efforts to synthesize it. Five total syntheses of Taxol have thus far been reported. Now, a combination of isolation of a related metabolite from European yew needles, and synthesis of Taxol from that intermediate, supply the clinical demand. This case clearly demonstrates the importance of synthesis and the use of organic chemistry. It's just one of the many examples used in the text that will spark the interest of students and get them involved in the study of organic chemistry!
This textbook was an amazing follow up read to a honors chemistry textbook such as Chemistry by Stephen Zumdahl. With that context in mind, I really loved reading this textbook and thoroughly exploring the complex subject of organic chemistry. The book covers everything from the basics of organic chemistry to the most complicated, intricate topics such as the biological applications of such organic chemistry. The book includes diagrams, charts, tables, is arranged in an aesthetically pleasing way, and the writing style is fluid and relatively to read. Being easy to read was a huge plus for this textbook; being interested in the material is not easy if it is a struggle to read the text. Having said this, the only complaint I have with this textbook is that it does require quite a lot of previous knowledge. This makes sense, as the subject is an advanced level of chemistry, but it does make this book not suitable for most people.
Im good at Chem, but I just hate it so much, I didn't work at my ap chemistry course for a whole semester and bought this book to study a week before the test and I got an awesome grade, it focuses more on different types of reactions and it's not that dense.