The Organic Chemistry of Drug Design and Drug Action

by Richard B. Silverman, Mark W. Holladay

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules.

This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage.

This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries.

Genres: Chemistry, Science, Nonfiction

536 pages, Hardcover

First published January 1, 1992

Reviews

[Laura]

The movie was definitely better.

[Rebecca · Rating 5 out of 5]

Fantastic

[Ranjan Acharyya · Rating 4 out of 5]

ood

[Abigail Gibbons · Rating 4 out of 5]

interesting

ch 8 was kinda wordy

[Jeffrey Romine · Rating 5 out of 5]

I very much liked the presentation of SAR in terms of mapping out the pharmacophore. I also thought the chapters at the end on metabolism and prodrugs were about the best I've seen.

[Elizabeth]

I heard Richard B. Silverman at a seminar he gave for the Pharmacology Department, "Selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative inhibitors" (thought I probably would have just left the title at "Selective neuronal nitric oxide synthase inhibitors", or, better yet, "Inhibitors that are selective for nNOS over eNOS or iNOS").