ADME

by Geoffrey T. Tucker, Amin Rostami-Hodjegan (Editor)

This comprehensive text focuses on the systems approach to simulating and predicting pharmacokinetic behavior (including metabolism-based drug-drug interactions), in patient populations using demographic, physiological, and genetic information, as well as input from in vitro studies of drug absorption and disposition. ADME emphasizes the use of direct experimental in vitro data obtained from human material (microsomes, cells, tissue slices, recombinant proteins) supported with prediction of relevant parameters from physicochemical properties. Key features

350 pages, Other Format

First published January 15, 2009