After graduating from high school, Betsy moved to New York City where she attended New York University and studied acting at the renowned Stella Adler Studio. She wrote the book for Cowgirls, a musical that she also performed in, which was staged across the country. In 1987, Betsy produced and performed in Caryl Churchill's Top Girls with fellow staff members from Phebe's bar on the Bowery, at the nearby New Theater.
Betsy was a prolific writer. During her life, she wrote numerous books, including a humorous memoir, Callie's Tally: An Accounting of Baby's First Year (Or, What My Daughter Owes Me), and the novel Snow. She also wrote many children's books under the pen name Howie Dewin.