Experience sampling methods (ESM) are the gold standard in studying people’s thoughts, feelings, and behavior in the context of daily life. In this open handbook, experts from the center for Research on Experience sampling and Ambulatory methods Leuven (REAL) join forces to provide up-to-date and empirically-based advice for designing, conducting, and analyzing data fromESM studies. The book is designed as a step-by-step guide that walks the reader through the different steps of an ESM starting from the type of research questions that can be formulated and how this translates into the design of the study; ethical issues; considerations that come into play when actually conducting the study, such as calculating sample size; choice of software; and the importance of briefing/debriefing. This guide also provides a thorough introduction to preprocessing and analyzing the resulting intensive longitudinal data, ending with some future developments in the areas of mobile intervention and passive sensing. As such, this handbook represents an open, complete, and up-to-date introduction to ESM research for novice and expert researchers alike.