Solid state chemistry of drugs

by Stephen R. Byrn

PART 1: INTRODUCTION TO THE SOLID-STATE CHEMISTRY OF DRUGS Chapter 1: Drugs as Molecular Solids PART 2: METHODS OF ANALYSIS Chapter 2: X-Ray Crystallography Chapter 3: The X-Ray Powder Diffraction Method Chapter 4: Microscopy Chapter 5: Thermal Methods of Analysis Chapter 6: Dissolution Testing Chapter 7: Particle-Size Analysis Chapter 8: Infrared Spectroscopy of Solids Chapter 9: Solid-State NMR Spectroscopy PART 3: POLYMORPHS, SOLVATES, AND AMORPHOUS FORMS Chapter 10: Polymorphs Chapter 11: Hydrates and Solvates Chapter 12: Amorphous Solids PART 4: PHYSICAL TRANSFORMATIONS OF CRYSTALLINE MATERIAL Chapter 13: Polymorphic Interconversions Chapter 14: Loss of Solvent of Crystallization PART 5: CHEMICAL TRANSFORMATION IN THE SOLID STATE Chapter 15: Theoretical Analysis of Solid-State Chemical Reactions Chapter 16: Oxidation Reactions Chapter 17: Additions of Solid-State Hydrolyses Chapter 18: Gas-Producing Decomposition Reactions Chapter 19: Photochemical Reactions Chapter 20: Thermal Reactions Chapter 21: Reaction Kinetics Chapter 22: Miscellaneous Topics

346 pages, Hardcover

First published January 1, 1999