Maple is a powerful computer algebra system that can manipulate equations symbolically, determine solutions numerically, and depict models visually. This makes Maple an ideal tool for enhancing understanding of important calculus concepts such as functions, limits, and derivatives. This handbook guides users, both new and experienced, through a tour of the intuitive Clickable Context Panel, the Expression Palettes, and several Maple Libraries. Various Maple approaches are applied to solving interesting differential calculus problems. In the end of the text, users investigate Explore, a feature unique to Maple that makes problem solving an interactive experience. There are some suggestions on how to blend Maple seamlessly into instruction and each chapter ends with a problem set for practice. This handbook is the perfect complement to any differential calculus course, and it is also great reference guide for practitioners.