Nongenotoxic Carcinogenesis

by A. Cockburn, Lewis L. Smith (Editor)

The majority of human chemical carcinogens are capable of damaging DNA and are loosely defined as "genotoxic". On the other hand some chemicals which are described as non-genotoxic appear to increase the incidence of rodent cancers only as a secondary consequence of other induced toxicity. The primary action does not involve DNA damage.
This book presents the concept of non-genotoxic carcinogenesis, including possible mechanisms of action. The papers presented by prominent workers provide a detailed insight into the complexity of the field.

240 pages, Hardcover

First published October 31, 1994