The Adaptive Heart

by Makoto Nagano, Naranjan S. Dhalla

This comprehensive reference presents illuminating contributions from an international roster of authorities exploring the adaptive mechanisms of the heart. The book examines the philosophy of adaptation, adaptational versus pathological alterations in the hypertrophied and failing myocardium, stress proteins and myocardial protection, the adaptation of the heart to norepinephrine, adaptation in postischemic myocardium, cardiovascular adaptation to physical training, the signal transduction system in heart failure, cardiac adaptations to hypertension, and the pharmacological modulation of cardiac hypertrophy in hypertensive patients. Also addressed are many fascinating questions on adaptive alterations in cardiac mass and configuration (beneficial or detrimental?); the clinical manifestation of patients with hereditary angioneurotic edema (is it altered by aging?; and oxygen damage to heart mitochondrial DNA. associated with age.

560 pages, Hardcover

First published November 1, 1994