The discovery of chlorpromazine 40 years ago and of other compounds for the treatment of psychiatric disorders had marked influence on clinical psychiatry and basic neuro-science. Since then, the development of psychopharmacology and theories of psychiatric disorders have become closely interrelated. On the occasion of the 70th birthday of Hanns Hippius - a pioneer of clinical psychopharmacology - leading experts in this field and related disciplines met to present their views and theories on psychiatric disorders. Future perspectives of drug development, genetic research, nosological and diagnostic concepts, and strategies for more specific treatment of various psychiatric disorders were presented. The reader is given broad insight into the research and clinical perspectives of psychiatry.