In recent years, the DNA sequence rearrangements, widespread in both prokaryotes and eurkaryotes, have been the subject of intense research effort. Gene Rearrangement describes the latest developments in genomic rearrangements in prokaryotes, the molecular basis of antigenic variation in African trypanosomes, and DNA amplification in eukaryotes. The volume is an ideal companion to Molecular Immunology, a previous title in the Frontiers in Molecular Biology series that described DNA rearrangement mechanisms for genes of the immune system.