The conference held at the Banbury Center of Cold Spring Harbor Laboratory in November 1989 brought together researchers working in areas of reproductive biology, molecular and cellular mechanisms of mutagenesis, mutation expression, and risk assessment. The contributions provide a broad perspective of the unique biological aspects of germ-cell mutations, with emphasis on male systems. Germ-line properties affecting the induction and recovery of such mutations, and variables affecting their rate and nature, are stressed. Annotation copyright Book News, Inc. Portland, Or.