Cytotoxic T Cells in HIV And Other Retroviral Infections

by Paul Racz

Cytotoxic T lymphocytes play a central role in containing the spread of the AIDS virus (HIV) as well as other retroviruses. This publication provides a broad overview of our current understanding of this immune response in the HIV-infected patient. With contributions from major laboratories throughout the world, the effector T lymphocyte response is described in virus-infected humans and also in non-human primates infected with monkey AIDS viruses. The precise molecular events which govern cytotoxic T cell recognition of HIV, the role of these cells in protecting against the progression of AIDS and the contributions of cytotoxic T lymphocytes to clinical manifestations of disease are thoroughly discussed. The functional characterization of these cells as well as their definition in tissues are also described.

178 pages, Hardcover

First published July 1, 1992