Because of a lack of training programs for clinicians engaged in patient research, this concise step-by-step instructional manual fills a void and offers the basic information needed by clinical investigators in all medical specialties. Written by highly experienced researchers, it provides a road map to give new investigators a framework for the fundamental issues they must address, such as how to design and conduct a research study, how to prepare a grant application, how to prepare a protocol, how to protect the rights of human subjects, how to handle conflicts of interest, how to analyze the results of a study, and how to write a scientific paper based on the results obtained.