This issue of Primary Clinics in Office Practice, Guest Edited by Dr. Mark B. Stephens, is devoted to Cardiovascular Disease. Articles in this issue State of the Overview of disease burden of cardiovascular disease from an epidemiologic perspective; Heavy Economic burden of heart disease with projections/implications for impact on the health care system; Prevention of Heart Disease; Coronary Artery Disease; Congestive Heart Failure; Valvular Heart Disease; Peripheral Vascular Disease; The Athlete’s Heart and Sudden Death; Metabolic systems thinking in heart disease; Women and Heart Disease; Heart Disease in Children; and Cardiac Imaging.