An international group of clinicians and biomedical scientists interested in abnormal cardiovascular structure and organ failure present their perspectives on inflammation and wound healing in cardiovascular disease. Emphasis is placed on expressions of wound healing, such as myocardial infarction and rupture, chronic ischemic heart disease, the dilated failing heart, myocarditis, endomyocardial fibrosis, and coronary restenosis following revascularization. The significance of the regulatory aspects of wound healing is also highlighted, which addresses the regulation of collagen turnover and collagen degradation in the diseased heart, aorta, and atherosclerotic lesion; the association between circulating peptide and steroid hormones and myocardial fibrosis; the role of locally produced peptides in promoting tissue repair; the potential association between angiotensin I-converting enzyme gene, polymorphism and cardiovascular risk; the regulation of fibrillar collagen gene expression. This text offers an enhanced perspective of inflammation and wound healing in cardiovascular disease. Essential information regarding wound healing in specific cardiovascular disease states such as myocardial infarction and rupture, congent manner that will be useful to all cardiologists and cardiac surgeons. This international group of authors also offers a stimulating analysis of the regulatory aspects of wound healing