Biopsy Pathology of Bone and Bone Marrow

by Bertha Frisch, S. Mitchell Lewis

This comprehensive text on the morphology of bone and bone marrow biopsies describes the features that are likely to be encountered in trephine biopsies in various pathologic conditions. Its coverage reflects important advances in surgical trephine biopsy technique, particularly the development of improved methods of plastic embedding of tissue. These methods, pioneered by one of the authors of this book, have made it possible to prepare semi-thin and undecalcified sections of bone marrow that reveal cytological detail previously unobtainable. The book systematically covers the diagnosis of bone and bone marrow histology, with emphasis on findings in iliac crest biopsies. After describing the normal histology of the bone and bone marrow, the authors detail the features of various pathologic conditions. Coverage encompasses the wide range of disorders in hematology, oncology, internal medicine, and osteology for which investigation by bone marrow biopsy is indicated. In addition, the authors consider the uses of bone and bone marrow biopsy for exploring the pathogenesis of cancer metastases, the stimulus of cytotoxicity, and other fundamental aspects of cellular biology. Numerous high-quality black-and-white and color illustrations enhance and clarify the text, and an appendix gives full details of biopsy procedures and histological staining and sectioning methods.

304 pages, Hardcover

First published February 1, 1985