This innovative reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve, and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid in the development of interventional pharmacological measures. It features coverage of developments in pulsed radiofrequency treatment of chronic neck, back, and sympathetic, and peripheral neuroma-derived pain. Coverage includes molecular approaches for studying pain, design of clinical trials for the evaluation of contemporary therapeutics, enhancement of analgesic activity with N-methyl-D-aspartate receptor antagonsits, and more.