This work on premenstrual syndromes covers topics ranging from basic scientific and clinical research to more controversial sociological and legal issues. Scientific data on brain chemistry is analyzed and tells of the effect of sex hormones on brain neurochemical functions. Clinical research data and findings by academic gynaecologists and psychiatrists are reviewed, including the pharmacology of progesterone and the most recent progesterone treatment strategies. Also considered are the cultural, psychological and cognitive factors of PMS, as well as issues such as PMS being used as a "legal defence" and self-help consumer groups now trying to meet the demand for effective treatment. Topics receiving special attention include the relationship of PMS to psychpathology, the endogenous opiate hypothesis, nutritional therapy and current techniques for the clinical evaluation and treatment of these syndromes.