This volume contains the proceedings of the Symposium on GHRH, GH, and IGF-1: Basic and Clinical Advances, held December 9-12, 1993, in San Diego, California. The papers cover the physiology of GHRH-somatostatin-GH-IGF-I axis, the effects of recombinant human GH and/or IGF-1 in catabolic illness, contemporary issues in growth and development, the effects of rhGH and IGF-I on intermediary and bone metabolism, and the use of GHRH, rhGH, and rhIGF-1 in aging.