Department chairs are the leadership “glue” that binds complex academic medical centers together. They need the competencies, skills, and approaches that will harness the intelligence, creativity, and commitment of faculty, students, residents and peers. Forward-thinking institutions are realizing that success depends on building relationships based on shared values and purpose. Leading, part of the AAMC Successful Medical School Department Chair Series, is required reading for current and prospective medical school department chairs, deans and associate deans, and others who work with chairs.