Advances in Protein Chemistry, Volume 51: Linkage Thermodynamics of Macromolecular Interactions

by Peter S. Kim (Series Editor), Frederic M. Richards (Series Editor), David S. Eisenberg (Series Editor)

This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

473 pages, Hardcover

First published May 15, 1998