Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

by Younggil Kwon

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

310 pages, Hardcover

First published January 1, 2001

Reviews

[Amanda--A Scientist Reads · Rating 3 out of 5]

A relatively dense book covering PK/PD experimental design and relevant calculations for a working scientist. It has been a useful reference and would probably come in somewhere in the Jr/Sr level of undergraduate work in difficulty, so it was a great refresher for someone newer to the field of pharmacology research. This is only a tangential topic to my work, which is likely why I found it so useful, someone who has all projects centered in PPDM would likely find it too basic.

Overall I'd recommend for those interested in PK, or those who want to expand their knowledge base when working in a diverse group setting (core teams, etc.).