Retinoids in Normal Development and Teratogenesis

by Gillian Morriss-Kay (editor)

Retinoic acid is of major importance in the regulation of normal gene expression in both embryonic and adult cells, through binding to, and activation of, specific retinoic acid receptors in the nucleus. Other nuclear receptors may bind to different retinoids. In the embryo, tissue and
stage-specific distribution patterns of the different receptors, and of the cytoplasmic retinoid binding proteins, provide an underlying basis for the richly varied and changing pattern of retinoid-related developmental gene expression. This book provides an up-to-date review of recent progress in
understanding the roles of retinoids in both normal and abnormal differentiation, morphogenesis, and pattern formation. It integrates molecular, cellular and embryonic approaches.

320 pages, Hardcover

First published June 25, 1992