This superb text features internationally recognized authorities; full coverage of both hemostasis and thrombosis; detailed treatment of vessel wall physiology; integration of basic science information with clinical management specifics; nearly 15,000 references; extensive cross-referencing and much more. New to this edition: coverage of molecular genetics of hemostatic proteins, tissue factor pathway of blood coagulation, wound healing and angiogenesis, pathogenesis of atherosclerosis, hemostatic abnormalities in AIDS, treatment of venous thromboembolism, thrombolytic therapy for coronary artery disease, anticoagulant therapy with common agents and mechanisms of action of antiplatelet drugs. This edition also includes 150 new illustrations and tables.