The Department of Defence (DOD) is adopting the joint all-domain command and control (JADC2) strategy with the goal of establishing a globally interconnected and information-centric operational environment for warfare. This approach, implemented under the Mission Partner Environment (MPE) architecture and the Secret and Below Releasable Environment (SABRE) "material solution," entails swift exchange of data and cooperation among coalition troops from ally nations during joint operations. The transition towards data-centricity in information systems is crucial for the secure exchange of data among various user levels and diverse applications in SABRE. This book introduces the concept of Holistic AI to improve the process.