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Heal Your Gut, Save Your Brain: The Five Pillars of Enhancing Your Gut and Optimizing Your Cognitive Health

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The brain and the gut are neurologically and biochemically connected via millions of nerves and the trillions of microbes that populate the intestines. Known as the gut-brain axis, this communication network between the two systems is vast and complex. Although scientists have known about this axis for some time, the assumption was that the gut needed the brain in order to function. Only recently has science given the gut its due credit in this relationship. Researchers are learning that the gut microbiome can influence certain physiological processes in the brain. Our microbiome can affect how we think and function—cognition, memory, motor control—for better or worse.
More and more, poor gut health is being linked to a decline in brain health, opening up possibilities for exciting new and effective treatments to prevent and even help to heal disease states associated with poor brain health. Much of the research is focused on three leading causes of neurodegeneration that doctors have been struggling to treat stroke, Parkinson’s, and Alzheimer’s. Much of the recent research highlights the connection between well-known risk factors for these disorders—including genetics, environmental toxins, diabetes, obesity, and heart disease—and poor gut health, reinforcing that the connection between gut and brain health we’re seeing isn’t coincidental.
As a gastroenterologist with a personal and professional interest in understanding the role the gut plays in brain health and in employing targeted treatments that can prevent cognitive decline, Dr. Nandi is poised to deliver this information to consumers. Heal Your Gut, Save Your Brain explains the emerging science, including the pathophysiology between the gut and these disorders, in lay terms. It also shows readers how simple changes to improve gut health—most of which are not currently part of a neurologist’s standard treatment protocol—can help them to
▪       achieve excellent brain health;
▪       preserve brain health to help prevent neurological disease; and
▪       dramatically improve recovery from devastating neurological disorders such stroke, Alzheimer’s, and Parkinson’s
Dr. Nandi’s accessible and simple program is based on five pillars, which include nutrition, movement, purpose, spirituality, and community, and offers an holistic approach to helping prevent and mitigate cognitive decline.


 
 

245 pages, Kindle Edition

Published October 1, 2024

222 people are currently reading
513 people want to read

About the author

Partha Nandi

8 books3 followers

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Displaying 1 - 30 of 74 reviews
Profile Image for Matt Kelland.
Author 4 books9 followers
September 8, 2024
I almost gave up on this when it started talking about "The Dr Nandi Plan" from the Mayo Clinic: I immediately got red flags about fad diets and hokey wellness programs aimed at people who get their medical advice from WebMD. But I persevered, and was glad I did.

Nandi explains how gut health affects your brain, in just enough detail to satisfy my scientific curiosity. He never gets overly complex, but at the same, he avoids making it feel like he's dumbing down the complexities of gastroenterology. (Obviously, he simplifies a lot, but it doesn't feel that way - an important distinction.) He shows how your gut affects your risk of Alzheimer's, Parkinson's, stroke, and other serious conditions, and then dives into the specific dietary issues that can affect it. He also explains how aging affects your digestive system, and why you need to change your diet as you get older.

He doesn't just talk about diet, though. He stresses the importance of factors such as community, spirituality, exercise and purpose. The science is sound: our state of mind plays a huge part in our physical health as well as our mental health. If you're isolated, sedentary, cynical and bored, you're likely to be in poor health, even if you eat well.

Nandi doesn't come across as preachy, which is a relief. Yes, he'll tell you in no uncertain terms about the damage that processed flour, dairy, sugars, salts and fats can do to you (which hit hard, as I was eating a cream doughnut at the time), and he recommends healthy foods, but he doesn't make you feel bad for not eating a good diet. He also stresses that everyone's microbiome is different, so there's no such thing as a perfect diet that suits everyone. It almost felt ayurvedic in its approach, especially as it stresses traditional Indian ingredients like turmeric.

Overall, it's quite an uplifting book. Nandi points out that his techniques - the aforesaid Nandi Plan - can have a significant effect on not only minimizing the risks but also reducing the effects of neurodegenerative diseases. Simply by changing the way you eat and making lifestyle changes, you can massively improve your long-term quality of life.

My one negative comment is that the recipes at the end felt a little out of place. They're all relevant, but there weren't enough of them to build a proper eating plan around. I would have preferred it if this book had focused on the science behind the gut/brain relationship, and the recipes had gone into a companion volume.

Disclaimer: I received a free advance review copy from the publisher.
Profile Image for MJ.
477 reviews2 followers
November 17, 2024
2.75 ⭐

There are some interesting connections to gut health and cognition here. Nandi mostly suggests a high fiber, vegetable only diet. I don't think that helps all gut issues but he spends most of his time on that philosophy.
153 reviews4 followers
August 9, 2024
This was really interesting and informative. The author's personal story about her father's illness was touching and made it more engaging to read. I was a little wary of the prescriptive nature of some of the advice around eating specific foods to prevent specific illnesses but ultimately, the advice is all around eating fresh, healthy foods and living life in a healthy, holistic manner; the author is not recommending expensive supplements or anything like that. I really loved the inclusion of the recipes at the end and will definitely be using them. I have no problem recommending this book.
I received an Arc from Book Sirens.
Profile Image for Jung.
1,966 reviews45 followers
December 14, 2024
The book "Heal Your Gut, Save Your Brain" by Partha Nandi emphasizes the profound connection between gut health and brain function, urging readers to see their microbiome as an ally in maintaining cognitive clarity and preventing neurodegenerative diseases. Through compelling research and actionable advice, Dr. Nandi illustrates how the trillions of microorganisms residing in the gut do far more than digest food—they actively influence mood, memory, and the progression of diseases like Alzheimer’s and Parkinson’s. By adopting mindful dietary practices and a lifestyle that prioritizes gut health, individuals can empower themselves to safeguard their cognitive well-being.

Dr. Nandi’s journey into the field of gut-brain research began with a personal tragedy: his father, Professor Uma Nandi, suffered a debilitating stroke that left him paralyzed on one side. This experience catalyzed Dr. Nandi’s exploration of the emerging science linking the gut microbiome to brain health. Traditionally, the gut was viewed as a passive organ subordinate to the brain, but new research reveals a bidirectional relationship mediated by millions of nerves and a vast microbial ecosystem. This communication system influences everything from emotional regulation to the progression of neurodegenerative diseases.

Groundbreaking findings underscore the gut-brain connection’s significance. For instance, studies reveal that stroke survivors often experience accelerated cognitive decline, with gut health playing a pivotal role in this trajectory. Similarly, Parkinson’s disease progression correlates strongly with changes in the gut microbiome, suggesting that interventions targeting gut health could potentially slow its devastating effects. The NIH-led Human Microbiome Project illuminated how each person’s microbiome serves as a unique biological fingerprint, influencing health more profoundly than genetics in many cases. An unbalanced gut microbiome not only predisposes individuals to physical ailments but also impacts mental clarity and emotional resilience.

The gastrointestinal (GI) system, often oversimplified as a “tube,” is more accurately described as a sophisticated control center. Its primary role is to regulate what enters the bloodstream, ensuring that beneficial nutrients pass through while harmful substances are blocked. The GI barrier, supported by the Enteric Nervous System, functions as a frontline defense. A healthy microbiome produces metabolites like short-chain fatty acids, which energize the GI barrier and support its integrity. Conversely, disruptions in the microbiome can lead to leaky gut syndrome, where inflammatory molecules escape into the bloodstream and even cross the blood-brain barrier, triggering chronic inflammation and cognitive decline.

Inflammation is a recurring theme in the book, as it plays a central role in the gut-brain axis. While acute inflammation is a protective response, chronic inflammation often signals a failing system. Subtle symptoms like distractibility, forgetfulness, and brain fog are early indicators of an imbalanced gut-brain connection. These signs, though easy to overlook, should prompt proactive measures to restore gut health before more serious conditions develop.

Dr. Nandi advocates a “food as medicine” approach, encouraging readers to view their kitchens as personal pharmacies. The foundation of gut health lies in a diverse, plant-based diet rich in whole foods and minimally processed ingredients. Cruciferous vegetables, leafy greens, and allium vegetables like garlic and onions provide essential nutrients and promote the growth of beneficial gut bacteria. Spices such as turmeric and ginger amplify anti-inflammatory effects, while fermented foods act as natural probiotics. Berries, with their anti-inflammatory properties and natural sweetness, offer an excellent alternative to processed sugars.

Home cooking emerges as a central theme in the book, not only for its nutritional benefits but also for fostering mindfulness and connection. Preparing meals encourages healthier choices, such as prioritizing fresh ingredients and avoiding processed foods. Sharing meals with loved ones transforms eating into a communal experience, reinforcing positive habits and supporting emotional well-being. Dr. Nandi suggests limiting restaurant outings to once per week and keeping processed foods to less than 25% of total caloric intake to maintain optimal gut health.

The book delves deeply into the specific dietary strategies for combating Alzheimer’s disease, which is increasingly viewed as a condition influenced by gut health. Research highlights a distinct “Alzheimer’s gut” microbiome characterized by heightened inflammation. Dietary interventions, such as the Mediterranean diet, show great promise in mitigating this risk. This diet emphasizes fiber-rich vegetables, legumes, and healthy fats while minimizing inflammatory foods like red meat and processed items. Supplements such as probiotics, vitamin D, and butyrate further support cognitive function by enhancing the gut-brain axis. Intermittent fasting, particularly the 16:8 method, is another tool for promoting cellular repair and reducing inflammation, which may help delay Alzheimer’s progression.

Parkinson’s disease also demonstrates strong ties to gut health, with early signs of the condition often manifesting in the digestive system. Researchers have identified specific bacterial imbalances in Parkinson’s patients, suggesting that modifying the microbiome could influence disease progression. Dietary recommendations for Parkinson’s include raw green vegetables, fiber-rich foods, and healthy fats, which collectively reduce inflammation and support neurological function. Avoiding high-temperature cooking methods and excessive consumption of animal products is equally important. Surprisingly, even sleep position can impact disease management; side sleeping enhances the brain’s waste removal system, helping clear harmful proteins associated with Parkinson’s.

Dr. Nandi’s holistic approach underscores the power of everyday choices in shaping long-term health outcomes. By focusing on whole, nutrient-dense foods and mindful eating practices, individuals can strengthen their microbiome and, in turn, protect their brains. The benefits extend beyond cognition to include improved digestion, better sleep, and reduced anxiety, creating a ripple effect of well-being. While there are no miracle cures, these practical strategies offer a pathway to maintaining independence and quality of life for as long as possible.

In conclusion, "Heal Your Gut, Save Your Brain" presents a compelling case for viewing gut health as the foundation of cognitive vitality. Through a combination of scientific insights and practical advice, Dr. Nandi empowers readers to take control of their health by nurturing their microbiome. By making thoughtful dietary and lifestyle changes, individuals can protect their brains, enhance their resilience, and embrace a more fulfilling, balanced life.
Profile Image for Erinn Camp.
519 reviews1 follower
January 13, 2025
Audiobook: this book is super science-y which is why I gave it a 3 rating - I was hoping for something written more for the right brained people. I loved how the author’s dedication to this came through in his stories about his father.
Profile Image for Sierra.
950 reviews
October 29, 2024
Great overview of how essential gut health is for your overall health & wellbeing.
Profile Image for JessQueen.
408 reviews6 followers
October 30, 2024
Heal Your Gut, Save Your Brain
by Partha Nandi MD - Mayo Clinic Press

Thanks to the ALC program by @librofm I was able to connect with Partha Nandi’s MD work and learn about new findings in terms of what we eat and how that impacts on our daily health but most importantly, how it impacts our long term health.

This is an amazing book to listen and learn carefully while taking down notes and sorting out what changes are needed, doable and especially which changes need to be done right now.

Nandi’s work is impressive and it creates awareness on Alzheimer’s, strokes and brain damage. It’s absolutely binge worthy!
Profile Image for Gerry Aclag.
7 reviews2 followers
September 29, 2024
First, a big thank you to BookSirens for providing me with an ARC of this book.

Heal Your Gut, Save Your Brain by Dr. Partha Nandi is a game-changer for anyone curious about the powerful link between gut health and brain function. I've been diving deep into brain health literature, Alzheimer's, dementia, and everything in between, but this book truly stands out from the rest of what I've read so far. It combines cutting-edge research with Dr. Nandi’s personal stories and practical advice to show how our gut impacts everything from mood to memory. He dives deep into how maintaining a healthy gut could be one of the best things we do to prevent diseases like Alzheimer’s, Parkinson’s, and even stroke.

What really stands out is how accessible this book is, despite the complex science behind it. Dr. Nandi breaks down the gut-brain connection without overwhelming the reader, offering easy-to-follow advice on diet, lifestyle changes, and natural remedies. The story of his father’s stroke adds a personal, relatable touch, reminding us that this isn't just theory—it’s real life. The way he frames health around his "Five Pillars" (Nutrition, Movement, Purpose, Community, and Spirituality) makes the book feel like a holistic guide to living better, not just another health fad.

𝗪𝗵𝗮𝘁 𝗜 𝗟𝗲𝗮𝗿𝗻𝗲𝗱 𝗙𝗿𝗼𝗺 𝗧𝗵𝗶𝘀 𝗕𝗼𝗼𝗸
1. The Gut-Brain Axis
The gut-brain axis, a communication highway between our gut and brain, was mind-blowing to learn about. Dr. Nandi explains how the bacteria in our gut produce neurotransmitters like serotonin that directly affect our mood and mental clarity. It’s crazy to think that an imbalance in gut bacteria could be linked to Alzheimer’s or Parkinson’s—this connection really reshaped my understanding of how interconnected our body systems are.
2. Chronic Inflammation and Its Impact on Cognitive Health
Inflammation is a silent killer—this one’s not new to me—especially when it comes to the brain. But Dr. Nandi’s take on how unchecked inflammation can lead to ‘leaky gut’—letting harmful bacteria slip into the bloodstream and wreak havoc on the brain—completely blew my mind. I hadn’t connected the dots like that before, and it really hit home how much what we eat can either protect or sabotage our brain.
3. The Role of Diet in Gut and Brain Health
The importance of what we put into our bodies is something I knew, but this book really hammered it home. The emphasis on prebiotics, probiotics, and a fiber-rich diet to maintain a healthy microbiome was a highlight for me. I’ve already started incorporating some of these tips, like cutting down on processed foods, because I now see the direct line between what’s happening in my gut and my brain.
4. Holistic Health: The Five Pillars
Beyond food, the Five Pillars show that gut health is about much more than what we eat. Movement, having a sense of purpose, and connecting with others are all pieces of the puzzle. I love how Dr. Nandi doesn’t just give us diet tips but encourages us to think bigger about our overall lifestyle. It’s not just about healing the gut, but healing the mind and body together.
5. Prevention and Management of Neurodegenerative Diseases
One of the most practical aspects of the book was the advice on preventing and managing neurological conditions through gut health. Intermittent fasting and the Mediterranean diet were two strategies that stood out as simple, actionable ways to reduce inflammation and boost brain health. It’s empowering to know that we have the tools to protect our brains through everyday choices.

𝗠𝘆 𝗙𝗮𝘃𝗼𝘂𝗿𝗶𝘁𝗲 𝗧𝗵𝗿𝗲𝗲 𝗟𝗶𝗻𝗲𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗕𝗼𝗼𝗸
1. "Our microbiome influences our health as much as or more than the genes we inherit from our parents."
2. "The gut-brain axis is not a one-way street; what happens in your gut can shape the very thoughts you think."
3. "Healing the gut, then, can truly save the mind."

𝗪𝗵𝗮𝘁 𝗜 𝗟𝗶𝗸𝗲 𝗟𝗲𝘀𝘀
As much as I enjoyed the book, it did tend to repeat certain concepts. For example, the impact of the microbiome on brain health is explained multiple times in different sections, which felt a bit redundant. Also, while I appreciated the focus on gut health, I would’ve loved to see more detail on the neurological processes at play—especially for readers who are into more in-depth science. Lastly, while the Indian-inspired recipes were great, offering a more diverse range of global options could’ve catered to a broader audience.

𝗥𝗮𝘁𝗶𝗻𝗴: 𝟱/𝟱
Heal Your Gut, Save Your Brain is a must-read for anyone serious about taking control of their health, especially those concerned with cognitive decline. Dr. Nandi’s approachable style and practical advice make it a powerful resource, despite a bit of repetition and a few areas lacking deeper scientific detail. When I read books like this, I’m all about putting the advice into action right away. I love using other people’s smarts and expertise to level up my own life, and honestly, it’s a strategy that’s done wonders for me. And for that I’m giving this book 5 stars.

I received an Advance Review Copy of this book from BookSirens for free, and I am leaving this review voluntarily.
5 reviews1 follower
September 3, 2024
When you open a book of this stature, you know it must have standards towards educating the masses over something the general individual really takes for granted: your gut. It really opened up my eyes to how delicate yet fortified the who G.I. system is at one given time. In the one hand, it is responsible for absorption of nutrients we feed in to it and at the same time, if damaged we're sick and green (or pale) to the face.

I felt shook when I thumbed through to get to all the chapters and I had to take a second take on almost every one because I feared I'd miss out key details pertinent to my health. Yet we haven't even begun to make the connection to what's going on upstairs in our head. Diet plays a crucial role in our overall health but we don't pay special attention to our self regulator: the command center. If no one's home in command, there's just an empty vessel.

I was taken aback by the sheer information laid out for me because if it's aim was to educate an average Joe (or Jane) about the physiological changes that starts from the epicenter, our gut, and spreads out so far as to reach command central, you'll see a painted picture of a severely stressed body, and you just cannot think of anything but the pain. My reaction was to immediately go get checked out by my PC doctor. I made up my mind that I've gone mindless about my health enough and it's time to take control. Would be in the best interest if everybody took it seriously too, since we've seen how lost and confused many of us are growing in population, but getting younger everyday. It's a wake up call, and I cannot thank the author enough for putting deeper thoughts into words with this book.

[I received an advance review copy for free, and voluntarily I'm leaving an honest review.]
Profile Image for Jenn.
95 reviews
October 5, 2024
I picked up Dr. Nandi's book Heal Your Gut, Save Your Brain for 2 reasons. One, because I'm interested in/curious about the effects of gut microbiota on general health. And two, because I have a family member that is dealing with Alzheimer's disease. Dr. Nandi's book, while a little dry and heavy on the science, was incredibly informative.

Dr. Nandi covers some general information about gut health and the 5 pillars of health (nutrition, movement, community, spirituality, and purpose), then goes in-depth on the specific ways that both affect Stroke, Alzheimer's, and Parkinson's prevention and treatment. I was shocked by a lot of the correlations between gut health and brain health.

This book isn't just for those dealing with the 3 main health issues covered. There is a bunch of information that is helpful in general, plus some tips for practical applications of the 5 pillars and how to incorporate beneficial foods and supplements. The handful of recipes included were good examples of the types of foods that promote a good gut microbiome in general, and that can potentially help those who are dealing with or wish to prevent stroke, Alzheimer's and Parkinson's.

4/5 stars. I found the scientific explanations a little overwhelming, but the suggestions for practical applications will be very helpful. Nothing was presented as a miracle cure or required extreme efforts to enact in your life.

I received an advance review copy for free, and I am leaving this review voluntarily. However, I found the information included so useful that I did purchase a copy for a family member.
Profile Image for Laurie.
1,002 reviews16 followers
April 29, 2025
As someone with gut issues, I try to read everything I can about the gut-brain connection. This book presented some new information in terms of how our gut can affect brain diseases such as Parkinson's, stroke, and Alzheimer's. Unfortunately, for me, most of the food recommendations and recipes contain things that I cannot eat. So, if you are lactose intolerant, have acid reflux, or eat a low FODMAP diet, you're probably going to wonder why these "gut-friendly foods" aren't good for your gut!!

"What is especially interesting to me is that our ancestors and even our great-grandparents did not set aside time for fitness; instead, it was incorporated into their daily life." - 6

"Numerous studies have found a clear connection between social relationships and four markers of health: blood pressure, waist circumference, body mass index, and even gut inflammation." - 7

In the U.S., 60 to 70 million people suffer from digestive disease - 15

Enteric nervous system: composed mostly of neurons - "the same type of cells found in the brain, but in this case lining the digestive tract" ... it first developed as an organism that did not have a brain "- 24

Vagus nerve - helps regulate a wide assortment of bodily functions from our ability to swallow to blood pressure - 25

prebiotic foods: artichokes, leeks, onions, garlic, asparagus, bananas, legumes, honey, oats, lentils - 99

gut-first Parkinson's hypotheses - abnormal alpha-synculein proteins escaping the gut and affecting the enteric nervous system - 158

side sleeping increases cerebrospinal fluid transport through the lymphatic system and could lead to improved brain health - 174

Profile Image for Sekar Writes.
262 reviews12 followers
July 31, 2024
Thank you Netgalley for the ARC as the exchange for my honest review.

When I first picked up this book, I expected it to be another typical guide on gut-brain health focused on diet. However, I was pleasantly surprised to find it offers more. The book introduces The Five Pillars: nutrition, movement, purpose, community, and spirituality. This comprehensive approach sets it apart from other gut health books, which usually stick to dietary advice or meditation or exercise for stress relief.

What makes this book unique is it offers a holistic solution. It blends Eastern and Western healing traditions, providing a fresh perspective on giving health advice. In addition, the insights offer practical changes to address diseases influenced by the gut-brain connection.

A particularly interesting feature is the collection of recipes at the end, aimed at improving gut health. This makes it easy to apply the book’s advice directly to everyday life.

Throughout the book, I encounter intriguing findings and helpful tips. While the healthy foods mentioned (like vegetables and high-fiber foods) might not be surprising, the way the book explains their impact on the gut-brain connection is intriguing. This combination of practical guidance and deeper understanding makes the book a valuable read for anyone interested in holistic health.
Profile Image for Jessica.
795 reviews
August 3, 2024
There’s been great scientific literature about the gut/brain connection and how taking care of one will help the other. In this book, the author talks about the five pillars we should work on to optimize our brain functions and how taking care of our gut health may help us avoid things like Parkinson's or a stroke.

I'm going to get out of the way the one thing I really didn’t like, but I have a feeling it’s something that’s going to be in every health book now. I cringed at the use of "holistic," and I wish I’d known about it before. The same goes for "spirituality" as one of the pillars. Probably a cultural thing (I am French), but I am neither religious nor spiritual and don’t plan to be; so obviously, the fact that those things are such a central part of the book kind of bothered me.

That being said, this is a book full of really good advice, and what I really liked is that it’s actionable advice. The author doesn’t tell us to change our entire lifestyle overnight; that would be unreasonable and unrealistic. We know the standard American (and just the standard Western) diet is not good for our overall health. We know that when we eat certain types of food, we feel worse mentally. It’s good to have a book that gives you really simple steps you can follow.

Thanks to Booksirens for the arc, "Heal Your Gut, Save Your Brain" will be out in November.
Profile Image for Whatithinkaboutthisbook.
293 reviews12 followers
August 6, 2024
Heal Your Gut, Save your Brain: The Five Pillars of Enhancing Your Gut and Optimizing Your Cognitive Health by Partha Nandi M.D.

I was interested in this book as I have experiencing cognitive decline. The author was drawn to her research following her father’s stroke, so has a personal investment in her research. It is organized around Five Pillars and teachers you to become a health hero.

There is a wealth of information and research in each chapter. Initially it focuses on teaching us the biology of the gut and understanding the gut/brain axis and how they communicate and influence each other.

The book highlights how poor gut health contributes to stroke, Alzheimers disease, and Parkinson’s disease. There are chapters dedicated to each condition and instructions on how you can change your lifestyle and eating habits to improve your gut health and consequently that condition, as well as your overall well-being. It concludes with recipes specific for each condition.

Although there is a lot of scientific information it is accessible to anyone and early understood. Although there is some repetition between the disease specific chapters, this is as a result of the overlap in the gut/brain axis.

This is a very informative book for anyone wanting to look at changing their health by following a more holistic approach involving a healthier lifestyle, structured eating habits that can be tailored the their area of concern.
Profile Image for Melissa.
1,228 reviews39 followers
November 3, 2024
𝑯𝑬𝑨𝑳 𝒀𝑶𝑼𝑹 𝑮𝑼𝑻, 𝑺𝑨𝑽𝑬 𝒀𝑶𝑼𝑹 𝑩𝑹𝑨𝑰𝑵 𝒃𝒚 𝑷𝒂𝒓𝒕𝒉𝒂 𝑵𝒂𝒏𝒅𝒊, 𝑴.𝑫. was a quick listen made available to me by @librofm.

I am no health nut, but the older I get, the more I am feeling the way food affects my body. This particular book goes through 5 ways we can affect our gut and how that, in turn, affects our brain. The brain affects are most focused on stroke, Alzheimer's, and Parkinson's. I'll leave the 5 ways for reading, but it isn't just what we eat, but also how we move and how we rest.

I appreciated how accessible this information was made. There is a fair amount of information given, proof of what is shown to help, and then it is broken down to simple ways to incorporate the information. The only thing that made me laugh a bit was the back and forth of animal products being bad, yet yogurt and cheeses being hailed as good! (I am sure it was meant to say meat products.) I am a massive cheese and yogurt fan, so this and the Mediterranean diet were not new to me, but nice confirmation of what I have heard previously.

Having my Celiac husband, I am familiar with the brain-gut connections, and yet I was still able to learn a bit more.
135 reviews2 followers
September 15, 2024
"Heal Your Gut, Save Your Brain" by Dr. Partha Nandi is a very interesting and informative guide that focuses on the biology of the gut, the understanding of the gut/brain axis, and how they communicate and influence each other. Its main highlight is the role that the microbiome in the gut plays in the health of your gut and how this can influence diseases such as Alzheimer's, Parkinson's, and stroke.

What makes this book unique is its practical, holistic approach. Dr. Nandi stresses the importance of factors such as pre and post biotics, and includes a practical guide to improve your food quality intake in order to improve your gut microbiome. This book doesn't just inform, it equips you with the tools to make a real difference in your health.

Dr. Nandi's book is a wake-up call to the damage that processed flour, dairy, sugars, salts and fats can do to your microbiome. It's a reminder of the urgent need to take control of your health and make positive changes.

Thanks to NetGalley and Mayo Clinic Press for the advanced reader's copy in exchange for an honest review!
45 reviews2 followers
August 2, 2024
A Comprehensive Guide to Gut and Brain Health

"Heal Your Gut, Save Your Brain" by Dr. Partha Nandi is a revelatory guide to understanding the powerful connection between our gut and brain. This book brilliantly underscores the crucial role of nutrition in nurturing our gut microbiome to enhance brain function, reduce inflammation, and combat cognitive decline. Dr. Nandi's deep dive into leaky gut syndrome and its impact on brain health is eye-opening!

The holistic approach, centered around five pillars of health—nutrition, movement, community, spirituality, and purpose—is both practical and inspiring. Dr. Nandi’s expertise is evident as he sheds light on the microbiome’s influence in preventing neurodegenerative diseases. This book is an essential read for anyone looking to improve their brain health through everyday, achievable steps. Highly recommended!
647 reviews
January 9, 2025
As with most books from Mayo Clinic Press, Heal Your Gut, Save Your Brain feels academic in nature, but the concepts are presented in a way that don't require the reader to have a doctorate in gastroenterology or neurology to understand. The author presents some case studies and frequently refers back to personal family history, which made this book almost feel like it was stepping into memoir territory, which I was not expecting and did not favor. The advice also tended toward overly-prescriptive for being a book, not a personal consultation.

A lot of similar findings are shared for each of the various diseases highlighted, which is great for specificity and if you are selectively reading this book to learn about the gut-brain connection for a particular disease, but because I read this seeking a deeper understanding of the gut-brain connection as it relates to health and longevity, the content felt repetitive to me. Dr. Nandi's five pillars of health - nutrition, movement, community, spirituality, and purpose - gave me some food for thought. I think this book will best serve someone who has a family history of a condition and is seeking advice specific to that.

Thank you to Mayo Clinic Press for gifting me with an ARC to review. All opinions are my own.
Profile Image for Ellie J.
177 reviews
July 21, 2025
While very interesting and full of helpful advice and information this book had a few major flaws that severely diminished it for me. For starters the author claims that religion is linked to better gut health, falling prey to the fallacy of correlation vs causation, then proceeds to mention religion once more in the entire book. If it’s one of the main pillars of health I expect proof of research as provided for every other pillar. Additionally there were 3 or 4 different sentences in the book where I understood what the author was trying to say, but they were not technically correct/ worded incorrectly. This severely impacted my credibility towards the author. Finally, many of the information was incredibly repetitive despite the short length of the book. It was an insightful read overall and I would suggest it to others simply for the insights gained.
Profile Image for Tara Garner.
49 reviews2 followers
August 12, 2024
Thank you NetGalley and Mayo Clinic Press for my advanced copy in exchange for my honest review!

Reading this book opened my eyes to so many new and natural ways I can try and heal my gut without feeling I have to run to the doctors. I appreciate that the author put his own experiences with his problems and shared ways that helped heal his gut. Definitely going to be trying the recipes that he put in the book and will be doing more meditation. I didn’t know that it could affect your gut health. As someone who has chronic stomach problems I appreciate the approach’s and precautions that are talked about.
Profile Image for Donna.
4,568 reviews171 followers
October 9, 2024
This one was just okay for me. For the last 3 years or so, I've been doing a deep dive into gut health and being metabollically healthy. So with that said, this didn't really give me anything new.

The author is pro plant based and gives all the same advice that is already out there in other books, Youtube university and Podcast Prep. But one thing that the author did well here was the way he linked everything together: gut health, brain health, and the WFPB way of life.

I'd recommend this to those who are new to this rabbit hole, but I'd also recommend researching other dietary approaches for all the pros and cons. So 3 stars.
Profile Image for Alicia Bayer.
Author 10 books252 followers
August 26, 2024
This is a great book with accessible information about how to use nutrition and other health changes to prevent or reverse Alzheimer’s, Parkinson’s and stroke. The focus is on a healthy gut but I was surprised at all the ways to keep the gut (and therefore brain) healthy besides just fermented foods, such as movement, fresh produce, avoiding pesticides and chemicals, spirituality, intermittent fasting, and even sleeping on your left side. Everything is backed up with studies and also case histories of patients the author helped.

I read a digital copy of this book for review.
Profile Image for Anna.
269 reviews
November 6, 2024
This book is easily digestible (pardon the pun!) and is very accessible information, even if you are not in the medical community. Dr. Nandi offers practical advice for improving your gut health, brain health and overall well being through the five pillars of health. Our guts are connected to everything else in our bodies and this book makes it easy to understand how and why to improve gut health. There are nutritional suggestions as well as a section of recipes.

Thanks to NetGalley for a free copy in exchange for honest review.
Profile Image for Synthia Salomon.
1,230 reviews19 followers
December 14, 2024
Gut and brain are connected

Nerves
Microbes

🦠
“your gut health profoundly impacts your brain health, particularly regarding neurodegenerative diseases like Alzheimer's and Parkinson's. 

The key to better health starts in your kitchen – cooking your own meals, moving towards a Mediterranean-style diet rich in plant foods, and being mindful of when and how you eat. 

Through simple but powerful changes in diet and lifestyle, you can actively protect your brain by nurturing your gut microbiome.”
This entire review has been hidden because of spoilers.
Profile Image for Katelyn.
30 reviews
July 1, 2025
My biggest takeaway is what I knew intuitivley in my gut and heart already. The gut is a barometer, sending us subtle signs of imbalance. We need to heed the warning signs, be in tune to what does not feel right, and get to the root issues through natural means. We especially in the West need to realize Western medicine isn't the end all be all and learn to utilize the healing rescources of our Eastern ancestors too. Let's just please stop being so stuck in our ways and actually care about healing people as opposed to merley bandaid fixing symtoms.
Profile Image for II.
67 reviews2 followers
December 15, 2025
I picked up this book without knowing that it talked about specific illnesses related to the brain (like stroke etc), I thought it would just be a general guide. However, I found it to be accessible in the writing style (and taking socioeconomic status into account as well).

The things he talked about are prevention-based and how to deal with these illnesses & taking into account different factors [He also gave tasty sounding recipes!]. I maybe would’ve liked a bit more on prayer or spirituality and community as he touched on them only a bit imo

I learned a lot and would recommend it!
1 review
October 1, 2024
Watching my husband, Dr. Partha Nandi, dedicate years to researching "Heal Your Gut, Save Your Brain" has been inspiring. His commitment to exploring the link between gut health and cognitive function was tireless, involving countless late nights and deep dives into scientific studies. This book is the result of his passion to help others live healthier lives, making complex science accessible and practical. I’m incredibly proud of the knowledge and care he’s put into every page.






Profile Image for Jquick99.
720 reviews15 followers
November 10, 2024
Does it irritate anyone else when authors write a sentence and then add on “if you will”.

Who says that in real life? Why isn’t that edited out?

I’m also NOT keen on starting chapters with stories of friends/patients/family members. For me, these are boring and just filler.

This author must be related to Dr. Gundry in that every disease can be related back to gut health. If you’ve read Gundry’s books, just move along …nothing new here.
Profile Image for Mir Shahzad.
Author 1 book8 followers
December 13, 2024
Summary:

Your gut health profoundly impacts your brain health, particularly regarding neurodegenerative diseases like Alzheimer's and Parkinson's.
The key to better health starts in your kitchen – cooking your own meals, moving towards a Mediterranean-style diet rich in plant foods, and being mindful of when and how you eat.
Through simple but powerful changes in diet and lifestyle, you can actively protect your brain by nurturing your gut microbiome.
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