It's probably next to impossible to write so detailed an account of the Space Shuttle's history without drowning it in acronyms and minutiae, and the book doesn't even try. It's strongest at the beginning and the end, when it's using relatively broad strokes to describe the Shuttle's development and a mid-2000s vision of its future and legacy, and in the sections that deal with the losses of Challenger and Columbia. Calling the bulk of the book in between these sections "dense" would be an understatement, and without the 13-page list of acronyms at the end much of it would be almost incomprehensible.
On the other hand, the step-by-step walkthrough of every mission prior to the post-Columbia return to flight gives a terrific set of insights into the challenges of performing even simple tasks in space and the obstacles to routinizing even simple activities beyond the Earth. Where it doesn't provide an easy or entertaining read, it makes a valuable reference tool for someone wishing to understand the ambition, the challenges, the accomplishments and the limitations of history's most versatile spaceship.